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A variety of media, supplemental media components, and reagents suitable for cell culture operations and processes. Products include fully prepared media as well as antibiotics, growth factors, contamination detection and removal reagents, cell dissociation reagents, and more.
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TFPI protein encoded by the TFPI gene is an important Kunitz-type serine protease inhibitor that regulates TF-dependent pathways in coagulation It inhibits factor X and VIIa-TF proteases preventing excessive clot formation TFPI Protein Human (HEK293 His) is the recombinant human-derived TFPI protein expressed by HEK293 with C-6 His labeled tag
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Ephb4 Protein a receptor tyrosine kinase plays a critical role in angiogenesis and development Dysregulation of Ephb4 Protein has been associated with disorders like cancer and cardiovascular diseases Targeting Ephb4 Protein may provide potential therapeutic interventions in these conditions by modulating angiogenesis inhibiting tumor growth and managing cardiovascular complications EphB4 Protein Mouse (HEK293 Fc) is the recombinant mouse-derived EphB4 protein expressed by HEK293 with C-hFc labeled tag
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VEGFR-1 protein is a tyrosine protein kinase receptor for VEGFA VEGFB and PGF and is critical for embryonic vasculature development angiogenesis cell survival migration macrophage function chemotaxis and cancer invasion It actively regulates postnatal retinal vitreous vascular degeneration and may act as a negative regulator of embryonic angiogenesis VEGFR-1 Protein Rat (HEK293 His) is the recombinant rat-derived VEGFR-1 protein expressed by HEK293 with C-His labeled tag
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Activin AB protein is a member of the transforming growth factor- (TGF- ) superfamily and plays a key role in various biological processes such as cell differentiation proliferation and apoptosis It is involved in embryonic development tissue repair and immune regulation FGF-9 Protein Human (HEK293 Fc solution) is the recombinant human-derived FGF-9 protein expressed by HEK293 with N-hFc labeled tag
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Activin A a multifunctional cytokine is a member of TGF- superfamily Activin A first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface and then recruits and phosphorylates type I activin receptors (ActRI) Activin A primarily signal through SMAD2/3 proteins to regulate a variety of functions including inflammation fibrosis and tumorigenesis Activin A Protein Mouse (HEK293 His) is produced in HEK293 cells with a C-Terminal His-tag
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ROR1 protein s minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo It serves as a receptor for WNT5A activating NFkB signaling and potentially inhibiting WNT3A signaling Notably ROR1 plays a vital role in the inner ear facilitating innervation of auditory hair cells by spiral ganglion neurons ROR1 Protein Human (sf9 His) is the recombinant human-derived ROR1 protein expressed by Sf9 insect cells with C-His labeled tag
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The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades Ligand binding induces receptor homo- or heterodimerization leading to autophosphorylation and recruitment of adapter proteins (such as GRB2) EGFR Protein Mouse (HEK293 Fc) is the recombinant mouse-derived EGFR protein expressed by HEK293 with C-hFc labeled tag
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The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades Ligand binding induces receptor homo- or heterodimerization leading to autophosphorylation and recruitment of adapter proteins (such as GRB2) EGFR Protein Mouse (HEK293 His) is the recombinant mouse-derived EGFR protein expressed by HEK293 with C-10 His labeled tag
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Azido-PEG4-Val-Cit-PAB-OH is a cleavable PEG-based linker used for assembling antibody-drug conjugates and other conjugates. It features an azide functional group for click chemistry and a protease-cleavable Val-Cit-PAB spacer that enables enzymatic payload release.
cleavable PEG-based linker for ADC and conjugate synthesis.
contains an azide group for CuAAC and SPAAC click reactions.
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ILK-IN-3 is an orally active small-molecule inhibitor of integrin-linked kinase (ILK) intended for research use. It has formula C10H12N6O and a molecular weight of 232.24 g/mol, and the batch COA reports LCMS purity of 99.62%. It has been reported to enhance the anticancer efficacy of docetaxel in orthotopic LCC6 models.
Orally active integrin-linked kinase (ILK) inhibitor
High reported purity (99.62% LCMS)
Suitable for in vitro and in vivo cancer model studies
Available in small mg-scale pack sizes for research (e.g., 5 mg)
Provided as a solid with defined molecular formula and weight
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Duocarmycin DM (free base) is a potent DNA minor-groove alkylating agent used as a cytotoxic payload in antibody-drug conjugate research and DNA-damage studies. It is supplied as a solid with high purity and is soluble in DMSO for in vitro or formulation use.
Potent DNA minor-groove alkylator for ADC payload research.
Molecular weight 463.96 g/mol; formula C26H26ClN3O3.
High purity (99.7%) suitable for preclinical studies.
Soluble in DMSO (~50 mg/mL) and formulatable for in vivo use.
Store long term at -20°C; protect from light and oxygen.
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The latency-associated peptide (LAP) of the transforming growth factor -1 (TGF- -1) proprotein is an important precursor that forms a complex with TGF- -1 LAP maintains the latent state of TGF- -1 during storage in the extracellular matrix ensuring controlled activation Interactions with environmental molecules such as LTBP1 LRRC32/GARP and LRRC33/NRROS intricately regulate TGF- -1 activation LRRC33/NRROS influences the activation of macrophages and microglia while LRRC32/GARP controls the activation of activated regulatory T cells Interactions with integrins induce conformational changes in LAP releasing active TGF- -1 LAP orchestrates controlled TGF- -1 activation in different physiological contexts Recombinant human TGF beta 1/TGFB1 LAP (biotinylated expressed in HEK293 cells Avi-tagged) is a biotinylated Avi-tagged LAP protein expressed in HEK293 cells[1][2]
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TSLP protein as a cytokine plays a key role in immune regulation It induces monocytes to release T-cell attracting chemokines and significantly promotes the maturation of CD11c( ) dendritic cells TSLP Protein Rat (HEK293 His) is the recombinant rat-derived TSLP protein expressed by HEK293 with C-His labeled tag The total length of TSLP Protein Rat (HEK293 His) is 118 a a with molecular weight of 20-30 kDa
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